NGS sequence analysis for regulation and epigenomics – Tim Bailey

This presentation will give a quick overview of the primary challenges and opportunities inherent in the analysis of next ‐ generation sequence analysis data. To make the most of the unprecedented detail and flexibility in DNA ‐ , RNA ‐ , and ChIP ‐ seq data, sequence analysis tools must be able to cope with the sheer volume of data generated and leverage the power this brings. At the same time, they must deal with the systematic biases present in data from any technological source, as well as biases caused by genomic “quirks” such as repeat elements and chromatin accessibility. Recently developed software tools grapple with these problems, but they must be used carefully.


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