Completing bacterial genomes using long sequencing reads: working towards the perfect genome assembly – Ryan Wick

Genome assemblers are tools which aim to reconstruct an original genome from sequencing reads. A ‘perfect’ assembler would take only reads as input and output a complete, error-free genome. This goal is usually impossible with short reads alone, but adding long reads from Oxford Nanopore sequencers brings it tantalisingly within reach. In this talk, I will describe the various ways genome assembly can fail and what researchers can do to achieve a perfect (or close to it) bacterial genome.


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