Category: 2018 WS Online Lectures

Classification and prediction ‘omics style – Nicola Armstrong

In this talk, we will explore different classification and prediction methods that are commonly used on ’omics data, and discuss the advantages and disadvantages of the various approaches. Quantifying the performance of a classifier and other important concepts that should … Read more

A need for caution in clustering and classifying high-dimensional data – Geoff McLachlan

In this talk, we illustrate the caution that needs to be exercised in the supervised and unsupervised classification of big data sets in bioinformatics. Issues that arise include whether a clustering obtained after much searching of the data represents a … Read more

Proteogenomics for accurate assembly and annotation of genomes – Harsha Gowda

One of the major goals of genome sequencing efforts is to provide an accurate assembly and annotation of all the genomic features including protein coding genes. Annotation of protein coding genes has been largely carried out using a combination of … Read more

Mutation detection in whole-genome sequencing – Ann-Marie Patch

Throughout landmark studies carried out as part of the Australian International Cancer Genome Consortium projects studying the molecular basis of pancreatic, ovarian and now melanoma tumours the development of robust mutation detection methods has been key. I am part of … Read more

Computational and infrastructure support for the biosciences – David Abramson

Bioscience applications have grown to require sophisticated computational and data management infrastructure. Modern bioscience data sets, whether they are gathered from scientific instruments such as microscopes, multi-modal scanners, or gene sequencers generate enormous amounts of data that must be stored … Read more

Next-generation sequencing – technology overview – Christopher Noune

The “Next-Generation Sequencing” landscape is one of constant change, with new and emerging technologies competing with established methods and platforms. Chris talks about the sequencing technologies that currently dominate the sequencing landscape, as well as those that are poised to … Read more

Designing effective vaccines – Justine Mintern

Receptor-targeted vaccination employs a new strategy of vaccine design whereby vaccine antigen is targeted directly to dendritic cells. Dendritic cells are the specialised cell type that initiate immune responses and receptor-targeted vaccination ensures efficient delivery of vaccine antigen. The approach … Read more

Bioinformatics analysis of single-cell RNA-seq data – Joshua Ho

In this lecture we will explore the characteristics of single-cell RNA-seq data, and discuss current bioinformatics methods and software that have been designed to analyse these data. Download

Exploring regulation through integration of high throughput sequencing data – Alexandra Essebier

High throughput sequencing (HTS) technology has contributed to a number of discoveries in the human genome. A handful of consortiums, including ENCODE and the Roadmap Epigenome, have generated thousands of HTS data sets describing different regulatory controls in the human … Read more

Data science and machine learning for bioinformatics – Kate Wathen-Dunn

Since 2012, sugarcane crops in Queensland have been affected by Yellow Canopy Syndrome (YCS) which is characterised by a specific pattern of leaf yellowing and an abnormal accumulation of sucrose and starch in the leaf. Currently, little is known about … Read more