Category: 2017 WS Online Lectures

Computational and infrastructure support for the biosciences – David Abramson

Bioscience applications have grown to require sophisticated computational and data management infrastructure. Modern bioscience data sets, whether they are gathered from scientific instruments such as microscopes, multi-modal scanners, or gene sequencers generate enormous amounts of data that must be stored … Read more

Mutation detection in whole-genome sequencing – Ann-Marie Patch

Through landmark studies carried out as part of the Australian International Cancer Genome Consortium projects studying the molecular basis of pancreatic, ovarian and now melanoma tumours the development of robust mutation detection methods has been key. Initially at the Queensland … Read more

Measuring methylation: from arrays to sequencing – Jovana Maksimovic

DNA methylation, which is the addition of a methyl group to the cytosine of a CpG dinucleotide, is one of the most widely studied epigenetic modifications in development and disease. Changes in DNA methylation are vital for normal development and … Read more

Using ultra high-throughput single cell sequencing to understanding cellular heterogeneity – Joseph Powell

The transcriptome is a key determinant of the phenotype of a cell and regulates the identity and fate of individual cells. Much of what we know about the structure and function of the transcriptome comes from studies averaging measurements over … Read more

An introduction to the field of single cell sequencing, and summary of progress and challenges – Joseph Powell

This talk will present an overview of the current state of the field of single-cell genome sequencing. First, focusing on the technical challenges of making measurements that start from a single molecule of DNA, and then explore how some of … Read more

MicroRNAs – sequencing, analysis … and then what? – Nicole Cloonan

MicroRNAs (miRNAs) are an important class of non-coding regulatory RNAs, which interfere with the translation of protein-coding mRNA transcripts. By incorporation into the RNA induced silencing complex (RISC), miRNAs can inhibit translation, promote sequestration of mRNAs to P-bodies, and/or destabilize … Read more

An introduction to RNA-seq – Paul Gardner

RNA-seq is a useful sequencing-based technology for identifying a snapshot of the transcriptional output from the cell. It has been used to estimate gene expression levels and estimate the impact of different treatments on gene expression. A new generation of … Read more

Personal notes on the advancements in synthetic biology – Kirill Alexandrov

Synthetic Biology is a hybrid discipline that combines biological sciences with engineering. It is ultimate goal is to build biological systems from ground up. In my presentation I will talk about the promises held by Synthetic Biology, the progress made … Read more

The emergent geography and geopolitical (mis)alignment of dispersal corridors and barriers across the Indo-West Pacific – Eric Treml

Although barriers to dispersal are known to contribute to the distinctiveness of communities, species and populations, the importance of the biophysical processes associated with permeable barriers is not well understood. In this research, I predict the geographic location and strength … Read more

How can bioinformatics help feed the world in 2050? – Dave Edwards

The global population is predicted to reach more than 9 billion by 2050, while at the same time, food production will become more challenging due to climate change. A new agricultural revolution, based on genomics and bioinformatics, is required to … Read more