Category: 2011 WS Online Lectures

Trees, networks, communities: mapping genetic transmission in the microbial biosphere – Mark Ragan

The year 1995 marked the beginning of the era of prokaryotic genomics, with publication of the complete sequence of Haemophilus influenzae ; today more than 2500 prokaryotic genomes are publicly available. Two discoveries so far have been particularly surprising: the … Read more

Molecular biology in a genomic age – John Quackenbush

A crucial aspect of what we will be learning in the Winter School is how, awash with increasing   volumes of genomic data, we can move from data to knowledge and from knowledge to understanding. One of the critical things that … Read more

Foundations of genomics, bioinformatics, and systems biology – John Quackenbush

The Central Dogma of Molecular Biology is that genes, encoded within the genome, are first   transcribed to RNA which is then translated into protein. It is these proteins, interacting with diverse elements form the pathways that regulate cellular processes. Genomics … Read more

Introduction to systems biology – Jessica Mar

The goal of systems biology is to derive working models of how individual components that make up a cell or organism interact to give rise to certain phenotypes, including the presence of disease. In recognition of how diverse and dynamic … Read more

Essential graph theory for biologists – Nicholas Hamilton

One of the simplest yet most useful structures in mathematics is the graph. The essence of a graph is to model pairwise relations between objects by defining a set of vertices or nodes and edges that connect the vertices. They … Read more

Structure, unstructure and systems biology – Philip Kim

Genomics and systems biology have made great progress in recent years. At the same time, constant progress has been made in structural biology. Combining expertise from these fields can be very insightful and modern bioscience is increasingly becoming an integrative … Read more

Computational rules underlying brain wiring development – Geoffrey Goodhill

Biological nervous systems routinely perform feats of information processing that vastly exceed the abilities of any current man-made computer. This computational power comes at least partly from the precise way in which neurons are connected together. But what are the … Read more

Analysing RNA-seq data: from reads to results – Alicia Oshlack

High-throughput sequencing of the transcriptome leads to the production of millions of short reads which need to be analysed in order to make biological inference. RNA-seq data are complex and the analysis involves a series of steps for which research … Read more

Differential expression analysis: RNA-seq – Davis McCarthy

As the cost of sequencing continues to decrease, RNA-Seq becomes an ever more attractive platform for studying gene expression. A common goal is the discovery of genes hat are differentially expressed between experimental conditions. The scale and nature of RNA-Seq … Read more

Detecting mutations using next-generation sequencing – Karin Kassahn

As part of the International Cancer Genome Consortium the Queensland Centre for Medical Genomics has established laboratory and computational infrastructure and expertise to analyse whole human genomes for the presence of DNA and RNA mutations and epigenetic marks underlying cancer. … Read more