Project Description

Dr Jue Ruan

Chinese Academy of Agricultural Sciences, China

Fast and accurate long-read assembly with wtdbg2

Long read bioinformatics and applications

Tuesday 2 July 2019

Dr Jue Ruan is a Chief Scientist of Innovation Team of Agricultural Genomics Technologies at Chinese Academy of Agricultural Sciences’ Agricultural Genomics Institute, Shenzhen, Guangdong, China. Dr Ruan received his BSc in Biology Science degree in 2004 from Life Science College, Nankai University, Tianjin, China. He completed his PhD in Bioinformatics at Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China in 2009. His research interests include algorithm development of de novo assembly and sequence alignment, and ultra-low frequency somatic mutation detection.

Existing long-read assemblers require tens of thousands of CPU hours to assemble a human genome and are being outpaced by sequencing technologies in terms of both throughput and cost. We developed a novel long-read assembler wtdbg2 that, for human data, is tens of times faster than published tools while achieving comparable contiguity and accuracy. It represents a significant algorithmic advance and paves the way for population-scale long-read assembly in future.