Project Description

Dr Martin Smith

Garvan Institute of Medical Research

RNAseq 2.0: a single molecule revolution

Long read bioinformatics and applications

Tuesday 2 July 2019

Martin is the Genomic Technologies Group Leader at the Kinghorn Centre for Clinical Genomics, located at the Garvan Institute of Medical Research in Sydney, Australia. He is a computational biologist from Canada with a background in genomics, microbiology and immunology. His work has focused on genome and transcriptome annotation using comparative genomics and machine learning. He has been using nanopore sequencing since 2014, with a heavy focus on transcriptomic applications.

High-throughput transcriptomic and epigenomic studies have substantiated the prevalence and dynamics of regulatory regions in the human genome, including the surprising diversity and contentious function of long non-coding RNAs. What additional layers of complexity can single-cell and single-molecule sequencing technologies unravel? How will the observation of native molecules in real-time improve our understanding of health and disease? I will describe genomic and computational strategies for functional transcriptome annotation using nanopore sequencing, with emphasis on targeted RNA sequencing, single cell sequencing, epitranscriptomics, and raw signal analysis.

Presentation slides will be available after the event.