Dr Martin Smith
Garvan Institute of Medical Research
Martin is the Genomic Technologies Group Leader at the Kinghorn Centre for Clinical Genomics, located at the Garvan Institute of Medical Research in Sydney, Australia. He is a computational biologist from Canada with a background in genomics, microbiology and immunology. His work has focused on genome and transcriptome annotation using comparative genomics and machine learning. He has been using nanopore sequencing since 2014, with a heavy focus on transcriptomic applications.
Single molecule, real-time sequencing promises to revolutionise the field of genomics. In particular, highly portable nanopore sequencers offer a trove of new bioinformatics possibilities, premised on the unique nature of the ‘noisy’ data. I will discuss the strengths and limitations of nanopore sequencing, with particular emphasis on practical and analytical challenges related to its peculiar data format. I will also detail methods and opportunities related to the analysis of raw ionic signal traces, with focus on transcriptomic and epi-transcriptomic applications.