Project Description

Dr Martin Smith

Garvan Institute of Medical Research

Nanopore sequencing: making music from noise

Long read bioinformatics and applications

Tuesday 2 July 2019

Martin is the Genomic Technologies Group Leader at the Kinghorn Centre for Clinical Genomics, located at the Garvan Institute of Medical Research in Sydney, Australia. He is a computational biologist from Canada with a background in genomics, microbiology and immunology. His work has focused on genome and transcriptome annotation using comparative genomics and machine learning. He has been using nanopore sequencing since 2014, with a heavy focus on transcriptomic applications.

Single molecule, real-time sequencing promises to revolutionise the field of genomics. In particular, highly portable nanopore sequencers offer a trove of new bioinformatics possibilities, premised on the unique nature of the ‘noisy’ data. I will discuss the strengths and limitations of nanopore sequencing, with particular emphasis on practical and analytical challenges related to its peculiar data format. I will also detail methods and opportunities related to the analysis of raw ionic signal traces, with focus on transcriptomic and epi-transcriptomic applications.

Presentation slides will be available after the event.